Midway via his career, Cees Dekker reinvented himself. Soon after many years of hardcore physics, he shifted his concentration to ‘nanobiology’ in the convert from the millennium. A expression he coined himself, as a issue of point.
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To be a human being, I possess the biblical assignment to examine and use everything in creation for the advantage of my neighbour. I will not experience any conflict among faith and science. Quite the opposite, my religion stimulates me to do science, for being open-minded on the earth.’
Given that 2000, Dekker has shifted the leading focus of his perform to biophysics exactly where he reports the Attributes of single biomolecules and cells using the equipment of nanotechnology. This alteration of field was driven by his fascination for that extraordinary functioning of biological molecular constructions, and also via the long-phrase viewpoint that lots of appealing discoveries is usually expected Within this area.[5] Recent traces of exploration in his biophysics team are from the parts of:[six]
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The coiled-coil in the human Rad50 DNA repair protein has certain segments of increased adaptability
Due to the fact 2000 he moved to solitary-molecule biophysics and nanobiology, with analysis from DNA supercoiling research of nucleosomes and DNA maintenance proteins to DNA translocation by nanopores. Just lately his analysis has centered on finding out cell division with microbes on chip, even though his greatest desire is from the path of realizing artificial cells.
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‘The fantastically refined way through which aspects in nature function hardly ever ceases to amaze me. If we address the puzzle of how daily life came into being, I hope that my amazement for the complexity of development may have increased and with it my awe for that greatness on the Creator.’
Screening pseudotopological and nontopological models for SMC-driven DNA loop extrusion from roadblock-traversal experiments
‘That concerns the synthetic mobile, as part of the Dutch BaSyC initiative. Craig Venter seemed major-down in Individuals times and identified about five hundred genes that happen to be minimally needed for the performing cell. We want to glance bottom-up: how do we go from the couple of molecules to a whole Organic system?
2005, discovery of your mechanism of DNA uncoiling by topoisomerase enzymes; discovery of very long-variety conformational variations in Mre11/DNA fix complexes; and initially force measurements over a DNA molecule in a nanopore
Sound-state nanopores have verified for being a incredibly adaptable probe for solitary-molecule Examination of DNA. I will describe a few of our current findings – specifically DNA knots – in addition to our efforts to expand the abilities of good-point out nanopores even further more, during the way of solitary-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.